Archive for Moderna

A Date for a Boost!

Posted in Biographical, Covid-19, Education with tags , , , , on December 9, 2021 by telescoper

After expressing concern about the prospects of getting a timely booster jab last night I received an SMS message offering me an appointment next Wednesday for a shot. The text was sent on 8th December, six months to the day since my second jab (8th June). I will once again have to travel to City West in order to receive it, so will have take some time off work but that’s a small price to pay.

I had inferred (incorrectly) that it would take much longer to get a date for booster because most of the people I know in their sixties haven’t had theirs yet and they are higher priority than me. I now realise that may be because they had the AstraZeneca vaccine, which had a longer interval between first and second doses than the 4 weeks for the Pfizer vaccine I had, so had a later second dose than mine.

My third vaccine dose will be of the Moderna vaccine; the previous two were Pfizer/BioNTech. It seems everyone who is getting a shot this month will be getting the Moderna version as Ireland has a large stock of this vaccine due to expire next month. Although its efficacy against the omicron variant is unknown, I will of course attend the appointment.

Yesterday, before I received the text message announcing my booster shot, I emailed the students in my classes to say the remaining lectures of the term will be online-only because of the high levels of Covid-19 in circulation and my waning immunity. Next week’s booster doesn’t change that as next week is the last week of teaching. My plan is to do the lectures live as webcasts and make the recordings available afterwards, which is how I’ve done them the entire term, except I’ll be doing them from home with no in-person audience. Apart, that is, from next Wednesday, when I’ll only be able to offer a pre-recorded lecture as I’ll be at City West when the lecture is scheduled. That will be my last lecture of the Semester, as most of my teaching is concentrated in the early part of the week.

Owing to a combination of Covid-19, Storm Barra and no doubt sheer exhaustion, student attendance at lectures and tutorials on campus has fallen sharply, though attendance at my second-year class has remained quite high. On Tuesday the campus was virtually deserted but about 70% of my class for Vector Calculus & Fourier Series were there. Somehiw, though, I don’t think they’ll mind too much watching the remaining couple of lectures from the comfort of their homes!

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SARS-Cov-2 Vaccine strategy: One Jab or Two?

Posted in Covid-19 with tags , , , , , on January 13, 2021 by telescoper

I’ve been thinking quite a lot about the issue of the Coronavirus vaccination programmes currently underway and have had some interesting and informative exchanges on Twitter about it. This morning’s news that AstraZeneca has finally applied to the European Commission for permission to market its vaccine within the European Union reminded me of those discussions so I thought I’d post a question here. I genuinely don’t know the answer, incidentally, so there’s no agenda here!

As you probably know all SARS-COV-2 vaccines (Moderna, Pfizer/Biontech and AstraZeneca) require two doses, administered about three weeks apart, for maximum efficacy. It’s worth saying before going on that the scientists involved deserve high praise for developing these highly effective vaccines at a speed that has exceeded all expectations.

At the moment however supplies of these vaccines are fairly limited and it’s early days for immunization programmes so there are serious logistical problems to be solved before we get anywhere near full vaccination. I grabbed this from Twitter yesterday showing the state of play in various countries:

Note, incidentally, that Denmark is doing particularly well within the EU but France, Netherlands, Luxembourg and Belgium have started very slowly. Ireland is about mid-table.

At the top of the league is Israel, though  they are not offering vaccination to the Palestinian people whose lands they occupy. Israel has just reported that after 12 days the Pfizer/BioNTech vaccine has about 50% efficacy after one dose based on results from its own programme. That number is roughly consistent with initial estimates of from trials this vaccine but the statistics aren’t great and there is a considerable margin of error on these figures.

Now the question I am asking myself is that given the limited supply is it better at this stage to give as many people as possible one dose of the vaccine, or follow the manufacturers’ original plan and give two doses to half as many people? There are reports that the UK has been deferring the second dose beyond the recommended interval, where there is no data on its efficacy. Perhaps I’m being excessively cynical but it seems to me that the UK Government’s approach is more driven by public relations than by public health considerations.

I understand that there are difficult issues here, not least the ethical one of having people sign up for a specific two-dose vaccination only to find that’s not what they get. Another issue is the speed with which doses are being made available relative to the size of the population. Yet another issue is who you prioritize.

Above all, though, there is the question of what you mean by “better”. One criterion would be to save as many lives as possible. Another might be to slow the rate of infections as much as possible. Another might be to allow the economy to open up as early as possible. These are all different and would lead to different decisions, particularly with regard to who should get the vaccine. Saving lives obviously means protecting the vulnerable and the people who care for them (e.g. health workers). Economic considerations would however lead you to prioritize those on whom the economy depends most directly, which would include workers who can’t easily work from home (many of whom are in low-paid manual jobs).

The following poll is therefore going to be very unscientific, but I’m interested to find out what people think. In  order to keep it simple, lets suppose you have a batch of two million doses of a vaccine (say the Pfizer one) and the next batch is due in three months.

You have to decide between the following two options:

  1.  Give 1,000,000 people one dose now and another dose in three weeks’ time
  2.  Give 2,000,000 people one dose now and hope that it is effective for three months (or that additional supplies appear more quickly than anticipated).

Vote now!

A similar poll I did on Twitter a while ago can be found here: there are some quite interesting comments in the ensuing thread.

Comments are of course welcome through the Comments Box!

P.S. I’m quite low down the pecking order in Ireland so it’s unlikely I’ll get vaccinated before the summer.

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